While entering one is not recommended, finding a door to a Boss Challenge Room can at least gauge Isaac's health by checking whether it's open or closed.Īmnesia pills don't incur the Curse of the Lost, thus being one less bad pill to worry about with False PHD an amnesia pill will also drop Black Heart on use for free. Turning the gamma setting up in the options can lessen the impact of Curse of Darkness. Refraining from deals can give access to Angel Rooms, which can provide items without the need to sacrifice health. While Devil deals can provide powerful items, taking one is very risky unless Isaac's health is carefully tracked. As well as this, Black Candle doesn't clear any of the curses in this challenge. This soundtrack contains all music from The Binding of Isaac: Rebirth, including all music tracks added in the Afterbirth, Afterbirth+, and Repentance DLC expansions. An analogue bull in the chip-tune china shop. Additionally, Curse of Darkness, although mostly just thematic, does contribute to the difficulty of the challenge by making it harder to spot tinted rocks, which normally would aid Isaac's survival with Soul Hearts. Drums were punished and voices scraped to the utmost. This also makes it especially risky when using mechanics that drain Isaac's health, such as devil deals or Blood Donation Machines. The curses inflicted are typically trivial on their own, however, they are the primary source of difficulty in this challenge due to the permanence of Curse of the Unknown, making it much more difficult to keep track of Isaac's health.